Anyone have first hand info on HGH?

[mayhem]

Did a search, and no results.

Does anyone have any first hand info on this stuff?

Does it work? Dangers? As usual the net is cluttered with products.

m

[lhslancers]

Did you Google human growth hormone? There is a lot of info out there. I have no first hand knowledge sorry.

[mayhem]

Did you Google human growth hormone? There is a lot of info out there. I have no first hand knowledge sorry.

Yeah, it is a interesting product. But I do trust the folks here, and respect their opinion, so that is why I asked the question.

Thanks, lancers...
m

[Anty Ep]

I know fairly well, a bodybuilder who for a long time and he took all diff kinds of roids both with and without prescriptions. HGH works, sure but for what? Especially when prescribed for growth hormone deficiency, but, just for off-label antiaging use, or for bodybuilding, there you are heading into the area of drug abuse. I say, if you have a health problem, start by talking to your doctor before you go taking roids.

Here is a good overview from a credible source.

http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/hum_0140.shtml

Human Growth Hormone and Secretagogues
TRADE NAMES

Recapture HGH (Transcend Marketing International), HGH 2000 (Global Nutrition), Eden GH1 (Nutribolics), Biogevity (Neways), Bioregenics GH (Oasis Wellness Network).
DESCRIPTION

Human growth hormone (HGH) is a heterogenous mixture of polypeptides secreted by the anterior pituitary gland. The principal form of HGH is a polypeptide containing 191 amino acids with a molecular weight of 215,000 daltons. This form of HGH is produced by recombinant DNA technology and is marketed for the treatment of short stature in growth hormone(GH)-deficient children and adolescents. Recombinant HGH or somatropin is also used for the treatment of GH deficiency in adults, short stature in association with renal insufficiency, AIDS-related wasting and short stature associated with Turner's Syndrome. In all of these cases, GH must be administered parenterally since it has very poor oral bioavailability.
GH is the primary hormone responsible for growth in humans, as well as other mammals, and it helps regulate such metabolic processes as anabolism and lipolysis. Normal human aging is associated with decreased GH secretion. Mean GH level in those over the age of 60 is about half of that in young adults. The reduction in GH levels with aging is believed to contribute to age-related decreases in muscle mass and strength and decreased lipolysis.
The effects of GH are largely mediated via IGF-1 (insulin-like growth factor 1). IGF-1 is a mitogen and may promote some cancers, including prostate, breast and colorectal cancers. Clearly, long-term safety studies, as well as efficacy studies, are essential to evaluate the role, if any, of GH replacement in the aging population.
The release of GH from somatotroph cells of the anterior pituitary gland is a complex process involving multiple regulators. The hypothalamic peptide GHRH (growth hormone-releasing hormone) acts on the somatotrophs to release GH, while the inhibitory peptide somatostatin blocks GH release. In addition, GH release appears to be influenced by a third, separate mechanism, as well—a growth hormone secretagogue pathway. GH secretagogues, abbreviated GHSs, can be amino acids, such as L-arginine, small peptides and nonpeptides. Further, neurotransmitters, such as acetylcholine, dopamine and norepinephrine, and neuropeptides, such as opioid peptides, are also involved in the control of GH secretion.
Recently, HGH has entered the dietary supplement marketplace, as have IGF-1 (see Insulin-Growth Factor 1) and several so-called GH secretagogues or releasers. The substances being marketed as GH secretagogues or releasers include the amino acids L-arginine, L-glutamine, L-ornithine, glycine, L-dopa, as well as such substances as ornithine alpha-ketoglutarate (see Ornithine Alpha-Ketoglutarate) and the herbs Macuna pruriens and Tribulus terrestris.
ACTIONS AND PHARMACOLOGY

ACTIONS

Supplemental HGH and secretagogues or releasers have putative anabolic and lipolytic activities, as well as putative "anti-aging" activity.
MECHANISM OF ACTION

The mechanism of the putative actions of supplemental HGH and secretagogues or releasers is unknown. The actions of endogenous GH and parenteral GH are thought to be mediated via the anabolic hormone IGF-1 and by interaction with specific GH receptors that are widely distributed in body tissues.
PHARMACOKINETICS

Orally administered GH has very poor bioavailability. It is claimed that GH is significantly absorbed from the oral mucosa if delivered by a spray. There is no substantiation for this. It is likely that orally administered GH is digested in the small intestine to the amino acids thah comprise the molecule.
INDICATIONS AND USAGE

There are no indications for the non-pharmaceutical use of HGH in any form. Claims that it is an anti-aging substance, that it enhances athletic and sexual performance, that it promotes joint health, is a sleep aid and an immune enhancer, that it has antidiabetic and antiatherosclerotic effects, and is a neuroprotector, are unsupported by credible evidence. Injected HGH may reduce fat and increase lean body mass in some, but serious side effects may attend the use of HGH for this purpose. There is preliminary evidence that injected HGH may be of benefit in some with Crohn's disease and that it might be helpful in treating dilated cardiomyopathy. There is some fear that high doses of HGH might promote some cancers.
RESEARCH SUMMARY

Recombinant human growth hormone, given parenterally to men aged 61 to 81, reportedly resulted in significant improvements in lean body mass, muscle tone, skin thickness and density of lumbar vertebrae. Significant loss of adipose tissue was also reported. The researchers concluded that "the effects of six months of human growth hormone treatment on lean body mass and adipose tissue were equivalent in magnitude to the changes incurred during 10 to 20 years of aging."
Subsequent studies also demonstrated some positive effects of HGH replacement therapy on body composition in those over 60. Some serious side effects were also noted, however, including arthralgias of both small and large joints, insulin resistance leading to higher serum fasting glucose levels, fluid retention in the lower extremities, carpal tunnel syndrome, gynecomastia and headaches. Due to the prevalence of some of these side effects, the researchers who conducted the first human trial reduced the dosage of HGH they had been using by half.
In a preliminary study, recombinant human growth hormone, given parenterally for three months to patients with idiopathic dilated cardiomyopathy, was reported to increase myocardial mass and reduce the size of the left ventricular chamber. These changes were associated with improved clinical status.
Recently, in another preliminary study, injected HGH was said to be beneficial in some with Crohn's disease. Improvement was measured by scores on the Crohn's Disease Activity Index over a four-month period.
There is no credible evidence that oral HGH has any health benefit.
CONTRAINDICATIONS, PRECAUTIONS, ADVERSE REACTIONS

(For information on the pharmaceutical use of somatropin, see Physicians' Desk Reference.)
CONTRAINDICATIONS

Supplemental human growth hormone is contraindicated in those with any evidence of active malignancy. It is also contraindicated in those who are hypersensitive to any component of an HGH-containing product.
PRECAUTIONS

Pregnant women and nursing mothers should avoid the use of HGH-containing supplements.
Adolescents should avoid the use of supplemental HGH.
Those with diabetes should avoid the use of supplemental HGH.
Oral forms of HGH are not meant to be used parenterally and should never be used in such a manner.
ADVERSE REACTIONS

None known for HGH-containing supplements.
INTERACTIONS

None known for HGH-containing supplements.
DOSAGE AND ADMINISTRATION

Oral recombinant human growth hormone is available and marketed as a dietary supplement, typically in the form of an oral spray. There are no recommended doses.
HOW SUPPLIED

Sublingual spray
LITERATURE

Bengtsson B-Å, Eden S, Lonn L, et al. Treatment of adults with growth hormone deficiency with recombinant human GH. J Clin Endocrinol Metab. 1993; 76:309-317.
Cohn L, Feller AG, Draper MW, Rudman IW, Rudman D. Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF-1 concentrations. Clin Endocrinol. 1993; 39:417-425.
Fazio S, Sabatini D, Capaldo B, et al. A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. 1996; 334:809-814.
Marcus R, Hoffman AR. Growth hormone as therapy for older men and women. Annu Rev Pharmacol Toxicol. 1998; 38:45-61.
Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990; 323:1-6.

[Anty Ep]

http://www.medscape.com/viewarticle/515665

that should throw some cold water on it

[mayhem]

http://www.medscape.com/viewarticle/515665

that should throw some cold water on it

Thanks for the info... I guess it is just "vanity":eek: on my part. I retired and sold my Insurance Damage Repair Co. two years ago at age 62. Now I have lost 15 lbs. of good muscle and tone even though I still work out 3 times a week.

Hey, sometimes you just chase all the rabbits...:clap2:

BTW: the link above, well I guess my firewall and or browzer settings won't allow it to load.

Thanks for the other info though.
Take care...

m

[Large Sarge]

I used it in the past, legally with a script, the anthrax vaccine I got in service causes all kinds of problems with the hypothalamus, it is pricey.

I can recommend a site for you, he does nutritional products, but also covers hormone replacement therapy.....

For your age I would say do it, but you should be on all the hormones, Thyroid, Test, etc

http://www.youngagainproducts.com/

search his articles, he is an honest fellow.

[mayhem]

I used it in the past, legally with a script, the anthrax vaccine I got in service causes all kinds of problems with the hypothalamus, it is pricey.

I can recommend a site for you, he does nutritional products, but also covers hormone replacement therapy.....

For your age I would say do it, but you should be on all the hormones, Thyroid, Test, etc

http://www.youngagainproducts.com/

search his articles, he is an honest fellow.

Thanks LS. I have to get out of here for a while. I'll look the link over later.

m